Clinical and histomorphometrical study on titanium dioxide-coated external fixation pins
نویسندگان
چکیده
BACKGROUND Pin site infection is the most common and significant complication of external fixation. In this work, the efficacy of pins coated with titanium dioxide (TiO(2)) for inhibition of infection was compared with that of stainless steel control pins in an in vivo study. METHODS Pins contaminated with an identifiable Staphylococcus aureus strain were inserted into femoral bone in a rat model and exposed to ultraviolet A light for 30 minutes. On day 14, the animals were sacrificed and the bone and soft tissue around the pin were retrieved. The clinical findings and histological findings were evaluated in 60 samples. RESULTS Clinical signs of infection were present in 76.7% of untreated pins, but in only 36.7% of TiO(2)-coated pins. The histological bone infection score and planimetric rate of occupation for bacterial colonies and neutrophils in the TiO(2)-coated pin group were lower than those in the control group. The bone-implant contact ratio of the TiO(2)-coated pin group was significantly higher (71.4%) than in the control pin group (58.2%). The TiO(2) was successful in decreasing infection both clinically and histomorphometrically. CONCLUSION The photocatalytic bactericidal effect of TiO(2) is thought to be useful for inhibiting pin site infection after external fixation.
منابع مشابه
Photoactive TiO2 antibacterial coating on surgical external fixation pins for clinical application
External fixation is a method of osteosynthesis currently used in traumatology and orthopedic surgery. Pin tract infection is a common problem in clinical practice. Infection occurs after bacterial colonization of the pin due to its contact with skin and the local environment. One way to prevent such local contamination is to create a specific coating that could be applied in the medical field....
متن کاملPrevention of pin tract infection with iodine-supported titanium pins.
BACKGROUND Pin tract infection is one of the most common complications of external fixation. We developed techniques to coat titanium implant surfaces with iodine. This study clinically evaluated the infection-preventive effects and biological safety of iodine-coated external fixation pins. PATIENTS AND METHODS Iodine-supported pins were placed in 39 limbs of 38 patients. The mean age of the ...
متن کاملHydroxyapatite pins for external fixation: is there sufficient evidence to prove that coated pins are less likely to be replaced prematurely?
OBJECTIVE Several clinical studies have reported that the use of hydroxyapatite- (HA) coated pins enhance external fixation. Although these studies have demonstrated higher extraction torques and lower rates of pin loosening with HA coating, there is little evidence to suggest that these biomechanical advantages translate to a lower rate of pin replacement prior to healing. The research questio...
متن کاملHydroxyapatite-coated external-fixation pins. The effect on pin loosening and pin-track infection in leg lengthening for short stature.
Pin loosening and infection are inherent complications of external fixation. This study deals with their effects of using either hydroxyapatite (HA)-coated or uncoated external fixation pins in leg-lengthening procedures on patients of short stature. We used HA-coated pins on one side and uncoated pins on the other (randomly determined) in 28 bilateral lengthenings undertaken in 23 patients. A ...
متن کاملBisphosphonate-coated external fixation pins appear similar to hydroxyapatite-coated pins in the tibial metaphysis and to uncoated pins in the shaft
BACKGROUND AND PURPOSE External fixation pins tend to loosen with time, especially from cancellous bone. A coating that releases a bisphosphonate has been shown to improve the fixation of dental implants in humans. We now tested a bisphosphonate coating on steel pins for external fixation. The primary hypothesis was that coated pins would be better fixed in the diaphysis. METHODS 20 patients ...
متن کامل